From 7bfbfb8bf211d9352bbc7040ad8e9e2fd729857b Mon Sep 17 00:00:00 2001 From: Christoph Helma Date: Tue, 8 Mar 2011 14:33:15 +0000 Subject: uni homepage added --- public/helma.html | 23 + views/publications.haml | 1522 +++++++++++++++++++++++------------------------ 2 files changed, 775 insertions(+), 770 deletions(-) create mode 100644 public/helma.html diff --git a/public/helma.html b/public/helma.html new file mode 100644 index 0000000..36a9e9b --- /dev/null +++ b/public/helma.html @@ -0,0 +1,23 @@ + + + Christoph Helma + + +

Christoph Helma

Contact:: Hermann Herder Str. 3
Westbau
D-79104 Freiburg
phone:+49-761-203-8442 / +41 774339164
email: helma_AT_in.silico.de
Research projects:: Lazar; Sens-it-iv; OpenTox; ToxBank; ModNanoTox; REACH categories
Publications
Spin-off company:: in silico toxicology

+ + diff --git a/views/publications.haml b/views/publications.haml index 0227781..f3d4ecc 100644 --- a/views/publications.haml +++ b/views/publications.haml @@ -1,770 +1,752 @@ -%dl - %dt - [ - %a{ :name => "maunz08b" } - 1 - ] - %dd - A. Maunz and C. Helma. - Prediction of toxic effects of pharmaceutical agents. - In K. V. Balakin, editor, - %em - Pharmaceutical Data Mining: Approaches - and Applications for Drug Discovery - , New York, 2009. J. Wiley & Sons, Inc. - [ - %a{ :href => "http://www.in-silico.de/articles/chapter_mh.pdf" } - \.pdf - \ ] - %dt - [ - %a{ :name => "maunz09a" } - 2 - ] - %dd - A. Maunz, C. Helma, and S. Kramer. - Large-scale graph mining using backbone refinement classes. - In - %em - Proceedings of the 15th ACM SIGKDD International Conference - on Knowledge Discovery and Data Mining (KDD-09) - , page in press, 2009. - [ - %a{ :href => "http://www.maunz.de/ls_graph_mining_using_bbrcs.pdf" } - \.pdf - \ ] - %dt - [ - %a{ :name => "hammann09a" } - 3 - ] - %dd - F. Hammann, H. Gutmann, U. Jecklin, A. Maunz, C. Helma, and J. Drewe. - Development of decision tree models for substrates, inhibitors and - inducers of P-glycoprotein. - %em - Current Drug Metabolism - , 10:339-46, 2009. - %dt - [ - %a{ :name => "hammann09b" } - 4 - ] - %dd - Felix Hammann, Heike Gutmann, Ulli Baumann, Christoph Helma, and Juergen Drewe. - Classification of cytochrome p(450) activities using machine learning - methods. - %em - Molecular pharmaceutics - , 6:1920-6, 2009. - %dt - [ - %a{ :name => "maunz08a" } - 5 - ] - %dd - A. Maunz and C. Helma. - Prediction of chemical toxicity with local support vector regression - and activity-specific kernels. - %em - SAR QSAR Environ. Res. - , 19:413-431, 2008. - [ - %a{ :href => "http://www.in-silico.de/articles/mh_tf.pdf" } - \.pdf - \ ] - %dt - [ - %a{ :name => "benigni07" } - 6 - ] - %dd - R. Benigni, T. I. Netzeva, E. Benfenati, C. Bossa, R. Franke, C. Helma, - E. Hulzebos, C. Marchant, A. Richard, Y.-T. Woo, and C. Yang. - The expanding role of predictive toxicology: an update on the (Q)SAR - models for mutagens and carcinogens. - %em - J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. - , - 25:53-97, 2007. - %dt - [ - %a{ :name => "helma06a" } - 7 - ] - %dd - C. Helma. - Lazy structure-activity relationships ( - %tt - lazar - ) for the - prediction of rodent carcinogenicity and - %em - Salmonella - mutagenicity. - %em - Molecular Diversity - , 10:147-158, 2006. - [ - %a{ :href => "http://www.in-silico.de/articles/modi020905.pdf" } - \.pdf - \ ] - %dt - [ - %a{ :name => "helma06b" } - 8 - ] - %dd - C. Helma and J. Kazius. - Artificial intelligence and data mining for toxicity prediction. - %em - Current Computer-Aided Drug Design - , 2:1-19, 2006. - [ - %a{ :href => "http://www.in-silico.de/articles/helma_kazius_ccadd.pdf" } - \.pdf - \ ] - %dt - [ - %a{ :name => "vracko06" } - 9 - ] - %dd - M. Vracko, V. Bandelj, P. Barbieri, E. Benfenati, Q. Chaudhry, M. Cronin, - J. Devillers, A. Gallegos, G. Gini, P. Gramatica, C. Helma, D. Neagu, - T. Netzeva, M. Pavan, G. Patlevicz, M. Randic, I. Tsakovska, and A. Worth. - Validation of counter propagation neural network models for - predictive toxicology according to the OECD principles. A case study. - %em - SAR QSAR Environ. Res. - , 17:265-84, 2006. - %dt - [ - %a{ :name => "helma05a" } - 10 - ] - %dd - C. Helma. - %em - Predictive Toxicology - \. - CRC Press, Boca Raton, 2005. - %dt - [ - %a{ :name => "helma05b" } - 11 - ] - %dd - C. Helma. - %tt - lazar: - Lazy Structure - Activity Relationships for toxicity - prediction. - In C. Helma, editor, - %em - Predictive Toxicology - , pages 479-499. CRC - Press, Boca Raton, 2005. - %dt - [ - %a{ :name => "helma05c" } - 12 - ] - %dd - C. Helma. - %em - In Silico - predictive toxicology: The state-of-the-art and - strategies to predict human health effects. - %em - Current Opinions in Drug Discovery & Development - , 8:27-31, - 2005. - [ - %a{ :href => "http://www.in-silico.de/articles/helma_coddd.pdf" } - \.pdf - \ ] - %dt - [ - %a{ :name => "helma05d" } - 13 - ] - %dd - C. Helma. - A brief introduction to predictive toxicology. - In C. Helma, editor, - %em - Predictive Toxicology - \. CRC Press, Boca - Raton, 2005. - %dt - [ - %a{ :name => "kramer05" } - 14 - ] - %dd - S. Kramer and C. Helma. - Machine learning and data mining. - In C. Helma, editor, - %em - Predictive Toxicology - , pages 223-254. CRC - Press, Boca Raton, 2005. - %dt - [ - %a{ :name => "helma04a" } - 15 - ] - %dd - C. Helma, T. Kramer, S. Kramer, and L. DeRaedt. - Data Mining and Machine Learning techniques for the - identification of mutagenicity inducing substructures and - Structure-Activity Relationships of noncongeneric compounds. - %em - J. Chem. Inf. Comput. Sci. - , 44:1402-1411, 2004. - [ - %a{ :href => "http://pubs3.acs.org/acs/journals/doilookup?in_doi=10.1021/ci034254q" } - http - \ ] - %dt - [ - %a{ :name => "helma04b" } - 16 - ] - %dd - C. Helma. - Data mining and knowledge discovery in predictive toxicology. - %em - SAR QSAR Environ. Res. - , 15:367-383, 2004. - %dt - [ - %a{ :name => "helma03a" } - 17 - ] - %dd - C. Helma and S. Kramer. - A survey of the Predictive Toxicology Challenge. - %em - Bioinformatics - , 19:1179-1182, 2003. - [ - %a{ :href => "http://bioinformatics.oxfordjournals.org/cgi/content/abstract/19/10/1179" } - http - \ ] - %dt - [ - %a{ :name => "helma03b" } - 18 - ] - %dd - C. Helma, S. Kramer, and L. DeRaedt. - The molecular feature miner MolFea. - In M. Hicks and C. Kettner, editors, - %em - Proceedings of the - Beilstein Workshop 2002: Molecular Informatics: Confronting Complexity - , - pages 79-93. Beilstein Institut, Frankfurt, 2003. - %dt - [ - %a{ :name => "toivonen03" } - 19 - ] - %dd - H. Toivonen, A. Srinivasan, R. D. King, S. Kramer, and C. Helma. - Statistical evaluation of the Predictive Toxicology Challenge - 2000-2001. - %em - Bioinformatics - , 19:1183-1193, 2003. - [ - %a{ :href => "http://bioinformatics.oxfordjournals.org/cgi/content/abstract/19/10/1183" } - http - \ ] - %dt - [ - %a{ :name => "helma02a" } - 20 - ] - %dd - C. Helma. - Data mining in toxicology. - In J.P.V. Heuvel, W.F. Greenlee, G.H. Perdew, and W.B. Mattes, - editors, - %em - Comprehensive Toxicology Vol XX. Cellular and Molecular - Toxicology - , pages 611-624. Elsevier, 2002. - %dt - [ - %a{ :name => "kassie02" } - 21 - ] - %dd - F. Kassie, S. Rabot, M. Uhl, W. Huber, H.M. Qin, C. Helma, R. Schulte-Hermann, - and S. Knasmüller. - Chemoprotective effects of garden cress (lepidium sativum) and its - constituents towards 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ)-induced - genotoxic effects and colonicneoplastic lesions. - %em - Carcinogenesis - , 23:1155-1161, 2002. - %dt - [ - %a{ :name => "kramer02" } - 22 - ] - %dd - S. Kramer, E. Frank, and C. Helma. - Fragment generation and Support Vector Machines for inducing - SARs. - %em - SAR and QSAR in Environmental Research - , 13:509-523, 2002. - %dt - [ - %a{ :name => "gottmann01" } - 23 - ] - %dd - E. Gottmann, S. Kramer, B. Pfahringer, and C. Helma. - Data quality in predictive toxicology: Reproducibility of rodent - carcinogenicity experiments. - %em - Environ. Health Perspect. - , 109:509-514, 2001. - [ - %a{ :href => "http://www.ehponline.org/members/2001/109p509-514gottmann/gottmann-full.html" } - \.html - \ ] - %dt - [ - %a{ :name => "helma01b" } - 24 - ] - %dd - C. Helma, R.D. King, S. Kramer, and A. Srinivasan. - The Predictive Toxicology Challenge 2000-2001. - %em - Bioinformatics - , 17:107-108, 2001. - [ - %a{ :href => "http://bioinformatics.oupjournals.org/cgi/reprint/17/1/107.pdf" } - \.pdf - \ ] - %dt - [ - %a{ :name => "kramer01e" } - 25 - ] - %dd - S. Kramer, L. De Raedt, and C. Helma. - Molecular feature mining in HIV data. - In - %em - Proceedings of the Seventh ACM SIGKDD International - Conference on Knowledge Discovery and Data Mining (KDD-01) - , pages 136-143, - 2001. - %dt - [ - %a{ :name => "helma00a" } - 26 - ] - %dd - C. Helma, S. Kramer, B. Pfahringer, and E. Gottmann. - Data quality in predictive toxicology: Identification of chemical - structures and calculation of chemical properties. - %em - Environ. Health Perspect. - , 108:1029-1033, 2000. - [ - %a{ :href => "http://ehpnet1.niehs.nih.gov/docs/2000/108p1029-1033helma/abstract.html" } - \.html - \ ] - %dt - [ - %a{ :name => "helma00b" } - 27 - ] - %dd - C. Helma, E. Gottmann, and S. Kramer. - Knowledge discovery and data mining in toxicology. - %em - Stat Methods Med Res. - , 9:329-358, 2000. - [ - %a{ :href => "http://www.in-silico.de/articles/smmr.pdf" } - \.pdf - \ ] - %dt - [ - %a{ :name => "helma00c" } - 28 - ] - %dd - C. Helma, S. Kramer, and B. Pfahringer. - Carcinogenicity prediction for noncongeneric compounds: Experiments - with the Machine Learning Program SRT and various sets of chemical - descriptors. - In - %em - Molecular Modelling and Prediction of Bioactivity - , page 464, - 2000. - %dt - [ - %a{ :name => "helma00d" } - 29 - ] - %dd - C. Helma and M. Uhl. - A public domain image analysis program for the single cell gel - electrophoresis (comet) assay. - %em - Mutation Res. - , 466:9-15, 2000. - [ - %a{ :href => "http://www.in-silico.de/articles/comet.pdf" } - \.pdf - \ ] - %dt - [ - %a{ :name => "helma00e" } - 30 - ] - %dd - C. Helma, E. Gottmann, S. Kramer, and B. Pfahringer. - The application of machine learning algorithms to detect chemical - properties responsible for carcinogenicity. - In K. Gundertofte and F.S. Jorgensen, editors, - %em - Molecular - Modeling and Prediction of Bioactivity - , pages 464-466, New York, 2000. - Kluwer Academic/Plenum Publishers. - %dt - [ - %a{ :name => "helma00f" } - 31 - ] - %dd - C. Helma, E. Gottmann, S. Kramer, and B. Pfahringer. - Artificial Intelligence Methoden zur Vorhersage der - Kanzerogenität organischer Verbindungen. - In H. Schöffl, H. Spielmann, and H.A. Tritthart, editors, - %em - Ersatz- und Ergänzungsmethoden zu Tierversuchen: Forschung ohne - Tierversuche - , pages 128-134, Wien-New York, 2000. Springer Verlag. - %dt - [ - %a{ :name => "uhl00" } - 32 - ] - %dd - M. Uhl, C. Helma, and S. Knasmüller. - Evaluation of the single cell gel electrophoretic assay with human - hepatoma (HepG2) cells. - %em - Mutation Res. - , 468:213-225, 2000. - %dt - [ - %a{ :name => "helma99a" } - 33 - ] - %dd - C. Helma, E. Gottmann, S. Kramer, and B. Pfahringer. - Data quality issues in toxicological knowledge discovery. - In - %em - Predictive Toxicology of Chemicals: Experiences and Impact of - AI Tools - , pages 8-11, Menlo Park, California, 1999. AAAI Press. - %dt - [ - %a{ :name => "pfahringer99" } - 34 - ] - %dd - B. Pfahringer, E. Gottmann, C. Helma, and S. Kramer. - Efficiency/representational issues in toxicological knowledge - discovery. - In - %em - Predictive Toxicology of Chemicals: Experiences and Impact of - AI Tools - , pages 86-89, Menlo Park, California, 1999. AAAI Press. - %dt - [ - %a{ :name => "uhl99" } - 35 - ] - %dd - M. Uhl, C. Helma, and S. Knasmüller. - Single-cell gel electrophoresis assays with human-derived hepatoma - (HepG2) cells. - %em - Mutation Res. - , 441:215-224, 1999. - %dt - [ - %a{ :name => "helma98a" } - 36 - ] - %dd - C. Helma, E. Gottmann, S. Kramer, and B. Pfahringer. - The application of machine learning algorithms to detect chemical - properties responsible for carcinogenicity. - In - %em - Molecular Modelling and Prediction of Bioactivity. - Proceedings of the 12th European Symposium on Quantitative Structure-Activity - Relationships - , 1998. - %dt - [ - %a{ :name => "helma98b" } - 37 - ] - %dd - C. Helma, P. Eckl, E. Gottmann, F. Kassie, W. Rodinger, H. Steinkellner, - C. Windpassinger, R. Schulte-Hermann, and S. Knasmüller. - Genotoxic and ecotoxic effects of groundwaters and their relation to - routinely measured chemical parameters. - %em - Environ. Sci. Technol. - , 32:1799-1805, 1998. - %dt - [ - %a{ :name => "knasmueller98" } - 38 - ] - %dd - S. Knasmüller, C. Helma, P. Eckl, E. Gottmann, H. Steinkellner, F. Kassie, - T. Haider, W. Parzefall, and R. Schulte-Hermann. - Investigations on genotoxic effects of groundwater from the - Mitterndorfer Senke from the vicinity of Wiener Neustadt. - %em - Wiener Klinische Wochenschrift - , 110:824-833, 1998. - %dt - [ - %a{ :name => "kramer98" } - 39 - ] - %dd - S. Kramer, B. Pfahringer, and C. Helma. - Stochastic propositionalization of non-determinate background - knowledge. - In - %em - Proceedings of the 8th International Workshop on Inductive - Logic Programming (ILP-98) - , pages 80-94, Berlin Heidelberg New York, 1998. - Springer. - %dt - [ - %a{ :name => "steinkellner98" } - 40 - ] - %dd - H. Steinkellner, M.S. Kong, C. Helma, S. Ecker, T.H. Ma, O. Horak, M. Kundi, - and S. Knasmüller. - Genotoxic effects of heavy metals: Comparative investigation with - plant bioassays. - %em - Environ. Mol. Mutagen. - , 31:183-191, 1998. - %dt - [ - %a{ :name => "helma97a" } - 41 - ] - %dd - C. Helma and S. Knasmüller. - Die Belastung von Gewässern mit gentoxischen Substanzen - IIa: Die Quellen gentoxischer Kontaminationen (Industrielle - Emissionen). - %em - UWSF-Z.Umweltchem.Ökotox. - , 9:41-48, 1997. - %dt - [ - %a{ :name => "helma97b" } - 42 - ] - %dd - C. Helma and S. Knasmüller. - Die Belastung von Gewässern mit gentoxischen Substanzen - IIb: Die Quellen gentoxischer Kontaminationen (Nichtindustrielle - Emissionen). - %em - UWSF-Z.Umweltchem.Ökotox. - , 9:163-168, 1997. - %dt - [ - %a{ :name => "helma97c" } - 43 - ] - %dd - C. Helma. - Die Situation der Chlorchemie in Östereich: Chlorhältige - Pflanzenschutz- Holzschutz und Wasserdesinfektionsmittel - Entwicklungen im - Zeitraum 1993 bis 1997. - Technical report, Gesellschaft Österreichischer Chemiker, 1997. - %dt - [ - %a{ :name => "knasmueller97" } - 44 - ] - %dd - S. Knasmüller, W. Parzefall, C. Helma, F. Kassie, S. Ecker, and - R. Schulte-Hermann. - Toxic effects of griseofulvin: Disease models, mechanisms, and risk - assessment. - %em - Critical Reviews in Toxicology - , 27:495-537, 1997. - %dt - [ - %a{ :name => "kramer97a" } - 45 - ] - %dd - S. Kramer, B. Pfahringer, and C. Helma. - Mining for causes of cancer: Machine learning experiments at various - levels of detail. - In - %em - Proceedings of the Third International Conference on - Knowledge Discovery and Data Mining (KDD-97) - , Menlo Park, CA, 1997. AAAI - Press. - %dt - [ - %a{ :name => "helma96a" } - 46 - ] - %dd - C. Helma, V. Mersch-Sundermann, V.S. Houk, U. Glasbrenner, C. Klein, - L. Wenquing, K. Fekadu, R. Schulte-Hermann, and S. Knasmüller. - Comparative evaluation of four bacterial assays for the detection of - genotoxic effects in water samples. - %em - Environ. Sci. Technol. - , 30:897-907, 1996. - %dt - [ - %a{ :name => "helma95" } - 47 - ] - %dd - C. Helma, L. Kronberg, T.H. Ma, and S. Knasmüller. - Genotoxic effects of the chlorinated hydroxyfuranones - 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone and - 3,4-dichloro-5-hydroxy-2[5H]-furanone in - %i - Tradescantia - micronucleus assays. - %em - Mutation Res. - , 346:181-186, 1995. - %dt - [ - %a{ :name => "helma95b" } - 48 - ] - %dd - C. Helma. - Erfahrungen mit dem Einsatz biologischer Mutationstests zur - Verfahrensoptimierung und Umweltkontrolle. - In - %em - Handbuch der Umwelttechnik 1995 - , pages 266-267. Wien, 1995. - %dt - [ - %a{ :name => "helma95c" } - 49 - ] - %dd - C. Helma. - Detection of genotoxic contaminations in water. - In M. Guminska and J. Miedzobrodzki, editors, - %em - Molecular Biology - for Environment and Man - , pages 99-111. 1995. - %dt - [ - %a{ :name => "helma94a" } - 50 - ] - %dd - C. Helma, R. Sommer, R. Schulte-Hermann, and S. Knasmüller. - Enhanced clastogenicity of contaminated ground water following UV - irradiation detected by the - %em - Tradescantia - micronucleus assay. - %em - Mutation Res. - , 323:93-98, 1994. - %dt - [ - %a{ :name => "helma94b" } - 51 - ] - %dd - C. Helma, S. Knasmüller, and R. Schulte-Hermann. - Die Belastung von Wässern mit gentoxischen Substanzen I. Methoden - zur Prüfung der Gentoxizität. - %em - UWSF-Z.Umweltchem.Ökotox. - , 6:277-288, 1994. - %dt - [ - %a{ :name => "helma94c" } - 52 - ] - %dd - C. Helma, S. Knasmüller, and R. Schulte-Hermann. - Biologische Tests zur Prüfung der Gentoxizität: - Einsatzmöglichkeiten zur Verfahrensoptimierung und Emissionskontrolle. - In Brandl et al., editor, - %em - Ecoinforma 94. Bd 9, Kanzerogenese - durch Umweltchemikalien - , pages 497-512. Wien, 1994. - %dt - [ - %a{ :name => "fassold93" } - 53 - ] - %dd - E. Fassold, C. Helma, S. Knasmüller, and R. Sattelberger. - Die Situation der Chlorchemie in Östereich, 8. Teil: - Chlorhältige Pflanzenschutz- Holzschutz und Wasserdesinfektionsmittel. - Technical report, Gesellschaft Österreichischer Chemiker, 1993. - %dt - [ - %a{ :name => "helma92" } - 54 - ] - %dd - C. Helma et.al. - Abfallarme Großküche. - Technical report, Österreichisches Ökologie Institut, 1992. - %dt - [ - %a{ :name => "helma91" } - 55 - ] - %dd - C. Helma et.al. - Ausstieg aus der Müllverbrennung. - Technical report, Österreichisches Ökologie Institut, 1991. +%dt + [ + %a{:name => "suenderhof10"}> 1 + ] +%dd + Claudia Suenderhauf, Felix Hammann, Andreas Maunz, Christoph Helma, and Jo�rg + Huwyler. + Combinatorial qsar modeling of human intestinal absorption. + = succeed "," do + %em Molecular Pharmaceutics + 8(1):213-224, 2011. + [ + %a{:href => "http://dx.doi.org/10.1021/mp100279d"}> DOI + \ | + %a{:href => "http://pubs.acs.org/doi/abs/10.1021/mp100279d"} http + ] +%dt + [ + %a{:name => "maunz10a"}> 2 + ] +%dd + Andreas Maunz, Christoph Helma, and Stefan Kramer. + Efficient mining for structurally diverse subgraph patterns in large + molecular databases. + = succeed "," do + %em Machine Learning + pages 1-26, 2010. + [ + %a{:href => "http://dx.doi.org/10.1007/s10994-010-5187-6"}> http + \ ] +%dt + [ + %a{:name => "hardy10"}> 3 + ] +%dd + Barry Hardy, Nicki Douglas, Christoph Helma, Micha Rautenberg, Nina Jeliazkova, + Vedrin Jeliazkov, Ivelina Nikolova, Romualdo Benigni, Olga Tcheremenskaia, + Stefan Kramer, Tobias Girschick, Fabian Buchwald, Joerg Wicker, Andreas + Karwath, Martin Gutlein, Andreas Maunz, Haralambos Sarimveis, Georgia + Melagraki, Antreas Afantitis, Pantelis Sopasakis, David Gallagher, Vladimir + Poroikov, Dmitry Filimonov, Alexey Zakharov, Alexey Lagunin, Tatyana + Gloriozova, Sergey Novikov, Natalia Skvortsova, Dmitry Druzhilovsky, Sunil + Chawla, Indira Ghosh, Surajit Ray, Hitesh Patel, and Sylvia Escher. + Collaborative development of predictive toxicology applications. + = succeed "," do + %em Journal of Cheminformatics + 2:7, 2010. +%dt + [ + %a{:name => "maunz08b"}> 4 + ] +%dd + A. Maunz and C. Helma. + Prediction of toxic effects of pharmaceutical agents. + In K. V. Balakin, editor, + = succeed "," do + %em + Pharmaceutical Data Mining: Approaches + and Applications for Drug Discovery + New York, 2009. J. Wiley & Sons, Inc. + [ + %a{:href => "http://www.in-silico.de/articles/chapter_mh.pdf"}> .pdf + \ ] +%dt + [ + %a{:name => "maunz09a"}> 5 + ] +%dd + A. Maunz, C. Helma, and S. Kramer. + Large-scale graph mining using backbone refinement classes. + In + = succeed "," do + %em + Proceedings of the 15th ACM SIGKDD International Conference + on Knowledge Discovery and Data Mining (KDD-09) + page in press, 2009. + [ + %a{:href => "http://www.maunz.de/ls_graph_mining_using_bbrcs.pdf"}> .pdf + \ ] +%dt + [ + %a{:name => "hammann09a"}> 6 + ] +%dd + F. Hammann, H. Gutmann, U. Jecklin, A. Maunz, C. Helma, and J. Drewe. + Development of decision tree models for substrates, inhibitors and + inducers of P-glycoprotein. + = succeed "," do + %em Current Drug Metabolism + 10:339-46, 2009. +%dt + [ + %a{:name => "hammann09b"}> 7 + ] +%dd + Felix Hammann, Heike Gutmann, Ulli Baumann, Christoph Helma, and Juergen Drewe. + Classification of cytochrome p(450) activities using machine learning + methods. + = succeed "," do + %em Molecular pharmaceutics + 6:1920-6, 2009. +%dt + [ + %a{:name => "maunz08a"}> 8 + ] +%dd + A. Maunz and C. Helma. + Prediction of chemical toxicity with local support vector regression + and activity-specific kernels. + = succeed "," do + %em SAR QSAR Environ. Res. + 19:413-431, 2008. + [ + %a{:href => "http://www.in-silico.de/articles/mh_tf.pdf"}> .pdf + \ ] +%dt + [ + %a{:name => "benigni07"}> 9 + ] +%dd + R. Benigni, T. I. Netzeva, E. Benfenati, C. Bossa, R. Franke, C. Helma, + E. Hulzebos, C. Marchant, A. Richard, Y.-T. Woo, and C. Yang. + The expanding role of predictive toxicology: an update on the (Q)SAR + models for mutagens and carcinogens. + = succeed "," do + %em J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. + 25:53-97, 2007. +%dt + [ + %a{:name => "helma06a"}> 10 + ] +%dd + C. Helma. + Lazy structure-activity relationships ( + %tt> lazar + ) for the + prediction of rodent carcinogenicity and + %em Salmonella + mutagenicity. + = succeed "," do + %em Molecular Diversity + 10:147-158, 2006. + [ + %a{:href => "http://www.in-silico.de/articles/modi020905.pdf"}> .pdf + \ ] +%dt + [ + %a{:name => "helma06b"}> 11 + ] +%dd + C. Helma and J. Kazius. + Artificial intelligence and data mining for toxicity prediction. + = succeed "," do + %em Current Computer-Aided Drug Design + 2:1-19, 2006. + [ + %a{:href => "http://www.in-silico.de/articles/helma_kazius_ccadd.pdf"}> .pdf + \ ] +%dt + [ + %a{:name => "vracko06"}> 12 + ] +%dd + M. Vracko, V. Bandelj, P. Barbieri, E. Benfenati, Q. Chaudhry, M. Cronin, + J. Devillers, A. Gallegos, G. Gini, P. Gramatica, C. Helma, D. Neagu, + T. Netzeva, M. Pavan, G. Patlevicz, M. Randic, I. Tsakovska, and A. Worth. + Validation of counter propagation neural network models for + predictive toxicology according to the OECD principles. A case study. + = succeed "," do + %em SAR QSAR Environ. Res. + 17:265-84, 2006. +%dt + [ + %a{:name => "helma05a"}> 13 + ] +%dd + C. Helma. + = succeed "." do + %em Predictive Toxicology + CRC Press, Boca Raton, 2005. +%dt + [ + %a{:name => "helma05b"}> 14 + ] +%dd + C. Helma. + %tt lazar: + Lazy Structure - Activity Relationships for toxicity + prediction. + In C. Helma, editor, + = succeed "," do + %em Predictive Toxicology + pages 479-499. CRC + Press, Boca Raton, 2005. +%dt + [ + %a{:name => "helma05c"}> 15 + ] +%dd + C. Helma. + %em In Silico + predictive toxicology: The state-of-the-art and + strategies to predict human health effects. + = succeed "," do + %em Current Opinions in Drug Discovery & Development + 8:27-31, + 2005. + [ + %a{:href => "http://www.in-silico.de/articles/helma_coddd.pdf"}> .pdf + \ ] +%dt + [ + %a{:name => "helma05d"}> 16 + ] +%dd + C. Helma. + A brief introduction to predictive toxicology. + In C. Helma, editor, + = succeed "." do + %em Predictive Toxicology + CRC Press, Boca + Raton, 2005. +%dt + [ + %a{:name => "kramer05"}> 17 + ] +%dd + S. Kramer and C. Helma. + Machine learning and data mining. + In C. Helma, editor, + = succeed "," do + %em Predictive Toxicology + pages 223-254. CRC + Press, Boca Raton, 2005. +%dt + [ + %a{:name => "helma04a"}> 18 + ] +%dd + C. Helma, T. Kramer, S. Kramer, and L. DeRaedt. + Data Mining and Machine Learning techniques for the + identification of mutagenicity inducing substructures and + Structure-Activity Relationships of noncongeneric compounds. + = succeed "," do + %em J. Chem. Inf. Comput. Sci. + 44:1402-1411, 2004. + [ + %a{:href => "http://pubs3.acs.org/acs/journals/doilookup?in_doi=10.1021/ci034254q"}> http + \ ] +%dt + [ + %a{:name => "helma04b"}> 19 + ] +%dd + C. Helma. + Data mining and knowledge discovery in predictive toxicology. + = succeed "," do + %em SAR QSAR Environ. Res. + 15:367-383, 2004. +%dt + [ + %a{:name => "helma03a"}> 20 + ] +%dd + C. Helma and S. Kramer. + A survey of the Predictive Toxicology Challenge. + = succeed "," do + %em Bioinformatics + 19:1179-1182, 2003. + [ + %a{:href => "http://bioinformatics.oxfordjournals.org/cgi/content/abstract/19/10/1179"}> http + \ ] +%dt + [ + %a{:name => "helma03b"}> 21 + ] +%dd + C. Helma, S. Kramer, and L. DeRaedt. + The molecular feature miner MolFea. + In M. Hicks and C. Kettner, editors, + = succeed "," do + %em + Proceedings of the + Beilstein Workshop 2002: Molecular Informatics: Confronting Complexity + pages 79-93. Beilstein Institut, Frankfurt, 2003. +%dt + [ + %a{:name => "toivonen03"}> 22 + ] +%dd + H. Toivonen, A. Srinivasan, R. D. King, S. Kramer, and C. Helma. + Statistical evaluation of the Predictive Toxicology Challenge + 2000-2001. + = succeed "," do + %em Bioinformatics + 19:1183-1193, 2003. + [ + %a{:href => "http://bioinformatics.oxfordjournals.org/cgi/content/abstract/19/10/1183"}> http + \ ] +%dt + [ + %a{:name => "helma02a"}> 23 + ] +%dd + C. Helma. + Data mining in toxicology. + In J.P.V. Heuvel, W.F. Greenlee, G.H. Perdew, and W.B. Mattes, + editors, + = succeed "," do + %em + Comprehensive Toxicology Vol XX. Cellular and Molecular + Toxicology + pages 611-624. Elsevier, 2002. +%dt + [ + %a{:name => "kassie02"}> 24 + ] +%dd + F. Kassie, S. Rabot, M. Uhl, W. Huber, H.M. Qin, C. Helma, R. Schulte-Hermann, + and S. Knasmüller. + Chemoprotective effects of garden cress (lepidium sativum) and its + constituents towards 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ)-induced + genotoxic effects and colonicneoplastic lesions. + = succeed "," do + %em Carcinogenesis + 23:1155-1161, 2002. +%dt + [ + %a{:name => "kramer02"}> 25 + ] +%dd + S. Kramer, E. Frank, and C. Helma. + Fragment generation and Support Vector Machines for inducing + SARs. + = succeed "," do + %em SAR and QSAR in Environmental Research + 13:509-523, 2002. +%dt + [ + %a{:name => "gottmann01"}> 26 + ] +%dd + E. Gottmann, S. Kramer, B. Pfahringer, and C. Helma. + Data quality in predictive toxicology: Reproducibility of rodent + carcinogenicity experiments. + = succeed "," do + %em Environ. Health Perspect. + 109:509-514, 2001. + [ + %a{:href => "http://www.ehponline.org/members/2001/109p509-514gottmann/gottmann-full.html"}> .html + \ ] +%dt + [ + %a{:name => "helma01b"}> 27 + ] +%dd + C. Helma, R.D. King, S. Kramer, and A. Srinivasan. + The Predictive Toxicology Challenge 2000-2001. + = succeed "," do + %em Bioinformatics + 17:107-108, 2001. + [ + %a{:href => "http://bioinformatics.oupjournals.org/cgi/reprint/17/1/107.pdf"}> .pdf + \ ] +%dt + [ + %a{:name => "kramer01e"}> 28 + ] +%dd + S. Kramer, L. De Raedt, and C. Helma. + Molecular feature mining in HIV data. + In + = succeed "," do + %em + Proceedings of the Seventh ACM SIGKDD International + Conference on Knowledge Discovery and Data Mining (KDD-01) + pages 136-143, + 2001. +%dt + [ + %a{:name => "helma00a"}> 29 + ] +%dd + C. Helma, S. Kramer, B. Pfahringer, and E. Gottmann. + Data quality in predictive toxicology: Identification of chemical + structures and calculation of chemical properties. + = succeed "," do + %em Environ. Health Perspect. + 108:1029-1033, 2000. + [ + %a{:href => "http://ehpnet1.niehs.nih.gov/docs/2000/108p1029-1033helma/abstract.html"}> .html + \ ] +%dt + [ + %a{:name => "helma00b"}> 30 + ] +%dd + C. Helma, E. Gottmann, and S. Kramer. + Knowledge discovery and data mining in toxicology. + = succeed "," do + %em Stat Methods Med Res. + 9:329-358, 2000. + [ + %a{:href => "http://www.in-silico.de/articles/smmr.pdf"}> .pdf + \ ] +%dt + [ + %a{:name => "helma00c"}> 31 + ] +%dd + C. Helma, S. Kramer, and B. Pfahringer. + Carcinogenicity prediction for noncongeneric compounds: Experiments + with the Machine Learning Program SRT and various sets of chemical + descriptors. + In + = succeed "," do + %em Molecular Modelling and Prediction of Bioactivity + page 464, + 2000. +%dt + [ + %a{:name => "helma00d"}> 32 + ] +%dd + C. Helma and M. Uhl. + A public domain image analysis program for the single cell gel + electrophoresis (comet) assay. + = succeed "," do + %em Mutation Res. + 466:9-15, 2000. + [ + %a{:href => "http://www.in-silico.de/articles/comet.pdf"}> .pdf + \ ] +%dt + [ + %a{:name => "helma00e"}> 33 + ] +%dd + C. Helma, E. Gottmann, S. Kramer, and B. Pfahringer. + The application of machine learning algorithms to detect chemical + properties responsible for carcinogenicity. + In K. Gundertofte and F.S. Jorgensen, editors, + = succeed "," do + %em + Molecular + Modeling and Prediction of Bioactivity + pages 464-466, New York, 2000. + Kluwer Academic/Plenum Publishers. +%dt + [ + %a{:name => "helma00f"}> 34 + ] +%dd + C. Helma, E. Gottmann, S. Kramer, and B. Pfahringer. + Artificial Intelligence Methoden zur Vorhersage der + Kanzerogenität organischer Verbindungen. + In H. Schöffl, H. Spielmann, and H.A. Tritthart, editors, + = succeed "," do + %em + Ersatz- und Ergänzungsmethoden zu Tierversuchen: Forschung ohne + Tierversuche + pages 128-134, Wien-New York, 2000. Springer Verlag. +%dt + [ + %a{:name => "uhl00"}> 35 + ] +%dd + M. Uhl, C. Helma, and S. Knasmüller. + Evaluation of the single cell gel electrophoretic assay with human + hepatoma (HepG2) cells. + = succeed "," do + %em Mutation Res. + 468:213-225, 2000. +%dt + [ + %a{:name => "helma99a"}> 36 + ] +%dd + C. Helma, E. Gottmann, S. Kramer, and B. Pfahringer. + Data quality issues in toxicological knowledge discovery. + In + = succeed "," do + %em + Predictive Toxicology of Chemicals: Experiences and Impact of + AI Tools + pages 8-11, Menlo Park, California, 1999. AAAI Press. +%dt + [ + %a{:name => "pfahringer99"}> 37 + ] +%dd + B. Pfahringer, E. Gottmann, C. Helma, and S. Kramer. + Efficiency/representational issues in toxicological knowledge + discovery. + In + = succeed "," do + %em + Predictive Toxicology of Chemicals: Experiences and Impact of + AI Tools + pages 86-89, Menlo Park, California, 1999. AAAI Press. +%dt + [ + %a{:name => "uhl99"}> 38 + ] +%dd + M. Uhl, C. Helma, and S. Knasmüller. + Single-cell gel electrophoresis assays with human-derived hepatoma + (HepG2) cells. + = succeed "," do + %em Mutation Res. + 441:215-224, 1999. +%dt + [ + %a{:name => "helma98a"}> 39 + ] +%dd + C. Helma, E. Gottmann, S. Kramer, and B. Pfahringer. + The application of machine learning algorithms to detect chemical + properties responsible for carcinogenicity. + In + = succeed "," do + %em + Molecular Modelling and Prediction of Bioactivity. + Proceedings of the 12th European Symposium on Quantitative Structure-Activity + Relationships + 1998. +%dt + [ + %a{:name => "helma98b"}> 40 + ] +%dd + C. Helma, P. Eckl, E. Gottmann, F. Kassie, W. Rodinger, H. Steinkellner, + C. Windpassinger, R. Schulte-Hermann, and S. Knasmüller. + Genotoxic and ecotoxic effects of groundwaters and their relation to + routinely measured chemical parameters. + = succeed "," do + %em Environ. Sci. Technol. + 32:1799-1805, 1998. +%dt + [ + %a{:name => "knasmueller98"}> 41 + ] +%dd + S. Knasmüller, C. Helma, P. Eckl, E. Gottmann, H. Steinkellner, F. Kassie, + T. Haider, W. Parzefall, and R. Schulte-Hermann. + Investigations on genotoxic effects of groundwater from the + Mitterndorfer Senke from the vicinity of Wiener Neustadt. + = succeed "," do + %em Wiener Klinische Wochenschrift + 110:824-833, 1998. +%dt + [ + %a{:name => "kramer98"}> 42 + ] +%dd + S. Kramer, B. Pfahringer, and C. Helma. + Stochastic propositionalization of non-determinate background + knowledge. + In + = succeed "," do + %em + Proceedings of the 8th International Workshop on Inductive + Logic Programming (ILP-98) + pages 80-94, Berlin Heidelberg New York, 1998. + Springer. +%dt + [ + %a{:name => "steinkellner98"}> 43 + ] +%dd + H. Steinkellner, M.S. Kong, C. Helma, S. Ecker, T.H. Ma, O. Horak, M. Kundi, + and S. Knasmüller. + Genotoxic effects of heavy metals: Comparative investigation with + plant bioassays. + = succeed "," do + %em Environ. Mol. Mutagen. + 31:183-191, 1998. +%dt + [ + %a{:name => "helma97a"}> 44 + ] +%dd + C. Helma and S. Knasmüller. + Die Belastung von Gewässern mit gentoxischen Substanzen + IIa: Die Quellen gentoxischer Kontaminationen (Industrielle + Emissionen). + = succeed "," do + %em UWSF-Z.Umweltchem.Ökotox. + 9:41-48, 1997. +%dt + [ + %a{:name => "helma97b"}> 45 + ] +%dd + C. Helma and S. Knasmüller. + Die Belastung von Gewässern mit gentoxischen Substanzen + IIb: Die Quellen gentoxischer Kontaminationen (Nichtindustrielle + Emissionen). + = succeed "," do + %em UWSF-Z.Umweltchem.Ökotox. + 9:163-168, 1997. +%dt + [ + %a{:name => "helma97c"}> 46 + ] +%dd + C. Helma. + Die Situation der Chlorchemie in Östereich: Chlorhältige + Pflanzenschutz- Holzschutz und Wasserdesinfektionsmittel - Entwicklungen im + Zeitraum 1993 bis 1997. + Technical report, Gesellschaft Österreichischer Chemiker, 1997. +%dt + [ + %a{:name => "knasmueller97"}> 47 + ] +%dd + S. Knasmüller, W. Parzefall, C. Helma, F. Kassie, S. Ecker, and + R. Schulte-Hermann. + Toxic effects of griseofulvin: Disease models, mechanisms, and risk + assessment. + = succeed "," do + %em Critical Reviews in Toxicology + 27:495-537, 1997. +%dt + [ + %a{:name => "kramer97a"}> 48 + ] +%dd + S. Kramer, B. Pfahringer, and C. Helma. + Mining for causes of cancer: Machine learning experiments at various + levels of detail. + In + = succeed "," do + %em + Proceedings of the Third International Conference on + Knowledge Discovery and Data Mining (KDD-97) + Menlo Park, CA, 1997. AAAI + Press. +%dt + [ + %a{:name => "helma96a"}> 49 + ] +%dd + C. Helma, V. Mersch-Sundermann, V.S. Houk, U. Glasbrenner, C. Klein, + L. Wenquing, K. Fekadu, R. Schulte-Hermann, and S. Knasmüller. + Comparative evaluation of four bacterial assays for the detection of + genotoxic effects in water samples. + = succeed "," do + %em Environ. Sci. Technol. + 30:897-907, 1996. +%dt + [ + %a{:name => "helma95"}> 50 + ] +%dd + C. Helma, L. Kronberg, T.H. Ma, and S. Knasmüller. + Genotoxic effects of the chlorinated hydroxyfuranones + 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5H]-furanone and + 3,4-dichloro-5-hydroxy-2[5H]-furanone in + %i Tradescantia + micronucleus assays. + = succeed "," do + %em Mutation Res. + 346:181-186, 1995. +%dt + [ + %a{:name => "helma95b"}> 51 + ] +%dd + C. Helma. + Erfahrungen mit dem Einsatz biologischer Mutationstests zur + Verfahrensoptimierung und Umweltkontrolle. + In + = succeed "," do + %em Handbuch der Umwelttechnik 1995 + pages 266-267. Wien, 1995. +%dt + [ + %a{:name => "helma95c"}> 52 + ] +%dd + C. Helma. + Detection of genotoxic contaminations in water. + In M. Guminska and J. Miedzobrodzki, editors, + = succeed "," do + %em + Molecular Biology + for Environment and Man + pages 99-111. 1995. +%dt + [ + %a{:name => "helma94a"}> 53 + ] +%dd + C. Helma, R. Sommer, R. Schulte-Hermann, and S. Knasmüller. + Enhanced clastogenicity of contaminated ground water following UV + irradiation detected by the + %em Tradescantia + micronucleus assay. + = succeed "," do + %em Mutation Res. + 323:93-98, 1994. +%dt + [ + %a{:name => "helma94b"}> 54 + ] +%dd + C. Helma, S. Knasmüller, and R. Schulte-Hermann. + Die Belastung von Wässern mit gentoxischen Substanzen I. Methoden + zur Prüfung der Gentoxizität. + = succeed "," do + %em UWSF-Z.Umweltchem.Ökotox. + 6:277-288, 1994. +%dt + [ + %a{:name => "helma94c"}> 55 + ] +%dd + C. Helma, S. Knasmüller, and R. Schulte-Hermann. + Biologische Tests zur Prüfung der Gentoxizität: + Einsatzmöglichkeiten zur Verfahrensoptimierung und Emissionskontrolle. + In Brandl et al., editor, + = succeed "," do + %em + Ecoinforma 94. Bd 9, Kanzerogenese + durch Umweltchemikalien + pages 497-512. Wien, 1994. +%dt + [ + %a{:name => "fassold93"}> 56 + ] +%dd + E. Fassold, C. Helma, S. Knasmüller, and R. Sattelberger. + Die Situation der Chlorchemie in Östereich, 8. Teil: + Chlorhältige Pflanzenschutz- Holzschutz und Wasserdesinfektionsmittel. + Technical report, Gesellschaft Österreichischer Chemiker, 1993. +%dt + [ + %a{:name => "helma92"}> 57 + ] +%dd + C. Helma et.al. + Abfallarme Großküche. + Technical report, Österreichisches Ökologie Institut, 1992. +%dt + [ + %a{:name => "helma91"}> 58 + ] +%dd + C. Helma et.al. + Ausstieg aus der Müllverbrennung. + Technical report, Österreichisches Ökologie Institut, 1991. -- cgit v1.2.3