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Diffstat (limited to 'test/data/enm/study-XLSX-012fa9ed-275d-43bf-996d-20ee50308991.json')
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diff --git a/test/data/enm/study-XLSX-012fa9ed-275d-43bf-996d-20ee50308991.json b/test/data/enm/study-XLSX-012fa9ed-275d-43bf-996d-20ee50308991.json deleted file mode 100644 index c65c5aa..0000000 --- a/test/data/enm/study-XLSX-012fa9ed-275d-43bf-996d-20ee50308991.json +++ /dev/null @@ -1,1016 +0,0 @@ -{ - "uuid": "XLSX-012fa9ed-275d-43bf-996d-20ee50308991", - "owner": { - "substance": { - "uuid": "XLSX-aacdfad8-f3d3-39f2-b662-0d8084e283ef" - }, - "company": { - "uuid": "XLSX-4bb81f08-059d-32ad-b5fd-71c6bcc6e0db", - "name": "FP7 MARINA" - } - }, - "citation": { - "title": "http://dx.doi.org/10.1371/journal.pone.0127174", - "year": "2015", - "owner": "P32 - KI" - }, - "protocol": { - "topcategory": "TOX", - "category": { - "code": "NPO_1709_SECTION", - "term": "http://purl.bioontology.org/ontology/npo#NPO_1709", - "title": "NPO_1709 LDH Release Assay" - }, - "endpoint": "Cell viability - cell membrane damage: Lactate dehydrogenase assay (LDH) (CytoTox 96® Non-radioactive cytotoxicity assay - Promega, G1780) ", - "guideline": [ - "Cytotoxicity using human monocyte-derived macrophages (HMDM)" - ] - }, - "parameters": { - "CHMO:0002774": "N", - "CLO_0000031": "HMDM", - "CLO_0000031 EFO_0004443": "Karolinska University Hospital, Stockholm, Sweden - buffy coats from healthy adult blood donors ", - "Cell culture conditions - Serum": "FBS (Gibco, 10500) ", - "Cell culture conditions - Serum concentration in growth medium": 0.1, - "Cell culture conditions - Serum concentration in treatment medium": "0,05%", - "Cell line/Type - Full name": "Primary human monocyte-derived macrophages (HMDM)", - "Dispersion agent": "water with 0,05% BSA", - "NPO_1952": "Y", - "NPO_1961": "Y", - "NPO_1969 OBI_0000272": "NANOGENOTOX Dispersion protocol (http://www.nanogenotox.eu/files/PDF/web%20nanogenotox%20dispersion%20protocol.pdf) ", - "OBI_0001911 BAO_0000114": "RPMI (Sigma, R0833)" - }, - "reliability": { - "r_isRobustStudy": "false", - "r_isUsedforClassification": "false", - "r_isUsedforMSDS": "false", - "r_purposeFlag": null, - "r_studyResultType": "experimental result", - "r_value": null - }, - "interpretation": { - "result": null - }, - "effects": [ - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 0, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 100 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 1, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 97.542 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 5, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 96.65 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 10, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 94.321 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 25, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 82.461 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 50, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 68.18 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 75, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 58.725 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 100, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 39.835 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 0, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 100 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 1, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 98.295 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 5, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 97.724 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 10, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 93.735 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 25, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 83.795 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 50, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 64.729 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 75, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 53.187 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 100, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 43.117 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 0, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 100 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 1, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 99.92 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 5, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 91.437 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 10, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 82.094 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 25, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 56.049 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 50, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 25.874 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 75, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 23.828 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 100, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 6, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 28.389 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 0, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 100 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 1, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 88.264 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 5, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 83.09 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 10, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 79.01 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 25, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 61.029 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 50, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 49.667 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 75, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 44.124 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 100, - "unit": "µg/ml" - }, - "Replicate": "Replicate 1", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 28.98 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 0, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 100 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 1, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 91.224 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 5, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 77.783 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 10, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 75.223 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 25, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 56.581 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 50, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 35.798 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 75, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 34.625 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 100, - "unit": "µg/ml" - }, - "Replicate": "Replicate 2", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 25.894 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 0, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 100 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 1, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 148.209 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 5, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 121.997 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 10, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 112.79 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 25, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 97.73 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 50, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 92.256 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 75, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 86.975 - } - }, - { - "endpoint": "% cell viability", - "conditions": { - "Concentration": { - "loQualifier": "=", - "loValue": 100, - "unit": "µg/ml" - }, - "Replicate": "Replicate 3", - "Time point": { - "loQualifier": "=", - "loValue": 24, - "unit": "h" - } - }, - "result": { - "unit": "%", - "loValue": 54.098 - } - } - ] -} |