1 files changed, 1016 insertions, 0 deletions
diff --git a/test/data/enm/study-XLSX-012fa9ed-275d-43bf-996d-20ee50308991.json b/test/data/enm/study-XLSX-012fa9ed-275d-43bf-996d-20ee50308991.json
new file mode 100644
index 0000000..c65c5aa
--- /dev/null
+++ b/test/data/enm/study-XLSX-012fa9ed-275d-43bf-996d-20ee50308991.json
@@ -0,0 +1,1016 @@
+{
+  "uuid": "XLSX-012fa9ed-275d-43bf-996d-20ee50308991",
+  "owner": {
+    "substance": {
+      "uuid": "XLSX-aacdfad8-f3d3-39f2-b662-0d8084e283ef"
+    },
+    "company": {
+      "uuid": "XLSX-4bb81f08-059d-32ad-b5fd-71c6bcc6e0db",
+      "name": "FP7 MARINA"
+    }
+  },
+  "citation": {
+    "title": "http://dx.doi.org/10.1371/journal.pone.0127174",
+    "year": "2015",
+    "owner": "P32 - KI"
+  },
+  "protocol": {
+    "topcategory": "TOX",
+    "category": {
+      "code": "NPO_1709_SECTION",
+      "term": "http://purl.bioontology.org/ontology/npo#NPO_1709",
+      "title": "NPO_1709 LDH Release Assay"
+    },
+    "endpoint": "Cell viability - cell membrane damage: Lactate dehydrogenase assay (LDH)  (CytoTox 96® Non-radioactive cytotoxicity assay - Promega, G1780) ",
+    "guideline": [
+      "Cytotoxicity using human monocyte-derived macrophages (HMDM)"
+    ]
+  },
+  "parameters": {
+    "CHMO:0002774": "N",
+    "CLO_0000031": "HMDM",
+    "CLO_0000031 EFO_0004443": "Karolinska University Hospital, Stockholm, Sweden - buffy coats from healthy adult blood donors ",
+    "Cell culture conditions - Serum": "FBS (Gibco, 10500) ",
+    "Cell culture conditions - Serum concentration in growth medium": 0.1,
+    "Cell culture conditions - Serum concentration in treatment medium": "0,05%",
+    "Cell line/Type - Full name": "Primary human monocyte-derived macrophages (HMDM)",
+    "Dispersion agent": "water with 0,05% BSA",
+    "NPO_1952": "Y",
+    "NPO_1961": "Y",
+    "NPO_1969 OBI_0000272": "NANOGENOTOX Dispersion protocol (http://www.nanogenotox.eu/files/PDF/web%20nanogenotox%20dispersion%20protocol.pdf) ",
+    "OBI_0001911 BAO_0000114": "RPMI (Sigma, R0833)"
+  },
+  "reliability": {
+    "r_isRobustStudy": "false",
+    "r_isUsedforClassification": "false",
+    "r_isUsedforMSDS": "false",
+    "r_purposeFlag": null,
+    "r_studyResultType": "experimental result",
+    "r_value": null
+  },
+  "interpretation": {
+    "result": null
+  },
+  "effects": [
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 0,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 100
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 1,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 97.542
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 5,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 96.65
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 10,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 94.321
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 25,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 82.461
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 50,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 68.18
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 75,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 58.725
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 100,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 39.835
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 0,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 100
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 1,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 98.295
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 5,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 97.724
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 10,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 93.735
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 25,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 83.795
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 50,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 64.729
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 75,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 53.187
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 100,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
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+        "unit": "%",
+        "loValue": 43.117
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
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+          "loValue": 0,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 3",
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+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 100
+      }
+    },
+    {
+      "endpoint": "% cell viability",
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+          "loValue": 1,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 3",
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+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 99.92
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 5,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 3",
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+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 91.437
+      }
+    },
+    {
+      "endpoint": "% cell viability",
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+          "loQualifier": "=",
+          "loValue": 10,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 3",
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+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
+      },
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+        "unit": "%",
+        "loValue": 82.094
+      }
+    },
+    {
+      "endpoint": "% cell viability",
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+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 25,
+          "unit": "µg/ml"
+        },
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+          "loQualifier": "=",
+          "loValue": 6,
+          "unit": "h"
+        }
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+        "unit": "%",
+        "loValue": 56.049
+      }
+    },
+    {
+      "endpoint": "% cell viability",
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+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 50,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 3",
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+          "loValue": 6,
+          "unit": "h"
+        }
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+        "unit": "%",
+        "loValue": 25.874
+      }
+    },
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+      "endpoint": "% cell viability",
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+          "loQualifier": "=",
+          "loValue": 75,
+          "unit": "µg/ml"
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+        "Replicate": "Replicate 3",
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+          "loValue": 6,
+          "unit": "h"
+        }
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+        "unit": "%",
+        "loValue": 23.828
+      }
+    },
+    {
+      "endpoint": "% cell viability",
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+          "loQualifier": "=",
+          "loValue": 100,
+          "unit": "µg/ml"
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+        "Replicate": "Replicate 3",
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+          "loValue": 6,
+          "unit": "h"
+        }
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+        "unit": "%",
+        "loValue": 28.389
+      }
+    },
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+      "endpoint": "% cell viability",
+      "conditions": {
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+          "loQualifier": "=",
+          "loValue": 0,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
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+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 100
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 1,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
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+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 88.264
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
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+          "loQualifier": "=",
+          "loValue": 5,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
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+        "unit": "%",
+        "loValue": 83.09
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
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+          "loQualifier": "=",
+          "loValue": 10,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 79.01
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 25,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 61.029
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 50,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 49.667
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 75,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 44.124
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 100,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 1",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 28.98
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 0,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 100
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 1,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 91.224
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 5,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 77.783
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 10,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 75.223
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 25,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 56.581
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 50,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 35.798
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 75,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 34.625
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 100,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 2",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 25.894
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
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+          "loQualifier": "=",
+          "loValue": 0,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 3",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 100
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 1,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 3",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 148.209
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 5,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 3",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 121.997
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 10,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 3",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 112.79
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 25,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 3",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 97.73
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 50,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 3",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 92.256
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 75,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 3",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 86.975
+      }
+    },
+    {
+      "endpoint": "% cell viability",
+      "conditions": {
+        "Concentration": {
+          "loQualifier": "=",
+          "loValue": 100,
+          "unit": "µg/ml"
+        },
+        "Replicate": "Replicate 3",
+        "Time point": {
+          "loQualifier": "=",
+          "loValue": 24,
+          "unit": "h"
+        }
+      },
+      "result": {
+        "unit": "%",
+        "loValue": 54.098
+      }
+    }
+  ]
+}