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+<h1>Read across toxicity predictions with nano-lazar</h1>
+
+</div>
+</div>
+<div class="presentation">
+<div class="slide" id="slide0">
+<h1 class="title">Read across toxicity predictions with nano-lazar</h1>
+
+<p class="center">Christoph Helma</p>
+<p class="center">in silico toxicology gmbh</p>
+<img alt="http://www.enanomapper.net/sites/all/themes/theme807/logo.png" class="center align-center" src="http://www.enanomapper.net/sites/all/themes/theme807/logo.png" />
+
+</div>
+<div class="slide" id="requirements">
+<h1>Requirements</h1>
+<ul class="simple">
+<li>Nanoparticle characterisation</li>
+<li>Toxicity measurements</li>
+</ul>
+</div>
+<div class="slide" id="enanomapper-data-import">
+<h1>eNanoMapper data import</h1>
+<ul class="incremental simple">
+<li>Nanoparticles imported: 464</li>
+<li>Nanoparticles with particle characterisation: 394</li>
+<li>Nanoparticles with toxicity data: 167</li>
+<li>Nanoparticles with toxicity data and particle characterisation: 160</li>
+</ul>
+</div>
+<div class="slide" id="enanomapper-toxicity-endpoints">
+<h1>eNanoMapper toxicity endpoints</h1>
+<ul class="incremental simple">
+<li>Toxicity endpoints: 41</li>
+<li>Toxicity endpoints with more than one measurement value: 22</li>
+<li>Toxicity endpoints with more than 10 measurements: 2</li>
+</ul>
+</div>
+<div class="slide" id="selected-data">
+<h1>Selected data</h1>
+<p>Protein corona dataset Au particles (106 particles)
+Toxicity endpoint:</p>
+</div>
+<div class="slide" id="read-across-procedure">
+<h1>Read across procedure</h1>
+<ul class="incremental simple">
+<li>Identify relevant fragments (significant correlation with toxicity)
+TODO list of fragments, number</li>
+<li>Calculate similarities (weighted cosine similarity, correlation coefficients = weights)</li>
+<li>Identify neighbors (particles with more than 0.95 similarity)</li>
+<li>Calculate prediction (weighted average from neighbors, similarities = weights)</li>
+</ul>
+</div>
+<div class="slide" id="future-development">
+<h1>Future development</h1>
+<ul class="simple">
+<li>Validation of predictions</li>
+<li>Applicability domain/reliability of predictions</li>
+<li>Accuracy improvements:
+- additional data
+- feature selection
+- similarity calculation
+- predictions (local regression models)</li>
+<li>Usability improvements:
+- additional data (extension of applicability domain, additional endpoints and chemistries)
+- inclusion of ontologies
+- descriptor calculation directly from core and coating chemistries</li>
+</ul>
+</div>
+<div class="slide" id="webinterface">
+<h1>Webinterface</h1>
+<p><a class="reference external" href="https://nano-lazar.in-silico.ch/predict">https://nano-lazar.in-silico.ch/predict</a></p>
+<p>Your recommendations?</p>
+</div>
+<div class="slide" id="source-code">
+<h1>Source code</h1>
+<p><a class="reference external" href="https://github.com/opentox/nano-lazar">https://github.com/opentox/nano-lazar</a></p>
+</div>
+</div>
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