index.html


1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84

<!DOCTYPE html>
<html lang="en">
  <head>
    <meta charset="UTF-8">
    <meta http-equiv="X-UA-Compatible" content="IE=edge">
    <meta name="viewport" content="width=device-width, height=device-height, initial-scale=1.0">
    <title>in silico toxicology gmbh</title>
    <link rel="stylesheet" type="text/css" href="style.css">
  </head>

  <body>
    <h1> <em>in silico</em> toxicology gmbh </h1>
    <hr>

    <em>in silico</em> toxicology is a research oriented company focussing on the development of
    <a href='http://en.wikipedia.org/wiki/Open_source_software' rel='external'>open source</a>
    predictive toxicology software and services. We are specialized in developing and applying advanced
    data mining algorithms for complex chemical and biological data.
    <p>
    <a href="https://lazar.in-silico.ch"><code>lazar</code></a> is our free webservice for toxicity predictions. <a href="https://git.in-silico.ch">Other developments</a> had to be abandoned due to the lack of funding for maintenance and development.

    <h2>Webservices</h2>
      <h3><a href="https://lazar.in-silico.ch">lazar</a></h3>
        <a href="https://lazar.in-silico.ch"><code>lazar</code></a> <em>(Lazy Structure- Activity Relationships)</em> makes toxicity predictions for chemical structures. It
        uses an automated and reproducible <em>read across</em> algorithm and shows rationales for predictions, applicability domain estimations and validation results in a clear
        graphical interface.
        Batch predictions are available <a href='mailto:helma@in-silico.ch'>on request</a>.

      <h3><a href="https://nano-lazar.in-silico.ch">nano-lazar</a></h3>
          <a href="https://nano-lazar.in-silico.ch"><code>nano-lazar</code></a> is a proof-of-concept application for read-across predictions of nanoparticle toxicities. The application was developed for the
          <a href='http://www.enanomapper.net' rel='external'>eNanoMapper</a> project, and will not be maintained.

      <h3><a href="https://aop.in-silico.ch">PubChem read across</a></h3>
          <a href="https://aop.in-silico.ch">PubChem read across</a> predicts potential gene/protein targets of chemical structures. This is a quick prototype, that will not be maintained.

<!--
    <h2>Container</h2>
    Our attempt to solve the problem of reproducible research. Our Docker repository provides self contained images, for easy installations and archival purposes.
-->

    <h2><a href="https://git.in-silico.ch">Code</a></h2>
      <a href="https://git.in-silico.ch">Source code</a> for our projects and publications.

    <h2><a href="http://scholar.google.com/citations?sortby=pubdate&user=D7z0GgoAAAAJ">Publications</a></h2>
    Please head to <a href="http://scholar.google.com/citations?sortby=pubdate&user=D7z0GgoAAAAJ">Google scholar</a>.


    <h2>EU Projects</h2>
      <dl>
        <dt> <a href='http://www.enanomapper.net' rel='external'>eNanoMapper</a> </dt>
        <dd> A Database and Ontology Framework for Nanomaterials Design and Safety Assessment </dd>

        <dt> <a href='http://www.toxbank.net' rel='external'>ToxBank</a> </dt>
        <dd> Supporting integrated data analysis and servicing of alternative testing methods in toxicology (WP leader) </dd>

        <dt> <a href='http://www.birmingham.ac.uk/generic/modnanotox/index.aspx' rel='external'>ModNanoTox</a> </dt>
        <dd> Modelling toxicity behaviour of engineered nanoparticles (WP leader) </dd>

        <dt> <a href='http://www.opentox.org' rel='external'>OpenTox</a> </dt>
        <dd> An open source predictive toxicology framework (scientific leader, WP leader) </dd>

        <dt> <a href='http://www.sens-it-iv.org/' rel='external'>Sens-it-iv</a> </dt>
        <dd> Novel testing strategies for in vitro assessment of allergens (WP leader) </dd>

        <dt> <a href='http://www.scarlet-project.eu/' rel='external'>Scarlet</a> </dt>
        <dd> Workshop on in silico methods for carcinogenicity and mutagenicity </dd>
    </dl>

    <h2>Awards</h2>
    <ul>
      <li>Research Price for Alternative Methods to Animal Experiments (German Federal Ministry on Consumer Protection, Food and Agriculture, 2005)
      <li>Research Prize for Cancer Research without Animal Experiments (Doctors Against Animal Experiments, 2006)
    </ul>
    <h2>Contact</h2>
      <em>in silico toxicology gmbh</em>
      <br>Rastatterstrasse 41
      <br>CH-4057 Basel, Switzerland
      <p>Email:<a href='mailto:helma@in-silico.ch'>helma@in-silico.ch</a>
      <br>Phone: +41-774339164
    <hr>
    &copy; <a href='http://www.in-silico.ch/'>in silico toxicology gmbh</a> 2004-2020

  </body>
</html>