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<h1> <em>in silico</em> toxicology gmbh </h1>
<hr>
<em>in silico</em> toxicology is a research oriented company focussing on the development of
<a href='http://en.wikipedia.org/wiki/Open_source_software' rel='external'>open source</a>
predictive toxicology software and services. We are specialized in developing and applying advanced
data mining algorithms for complex chemical and biological data.
<p>
<a href="https://lazar.in-silico.ch"><code>lazar</code></a> is our free webservice for toxicity predictions. <a href="https://git.in-silico.ch">Other developments</a> had to be abandoned due to the lack of funding for maintenance and development.
<h2>Webservices</h2>
<h3><a href="https://lazar.in-silico.ch">lazar</a></h3>
<a href="https://lazar.in-silico.ch"><code>lazar</code></a> <em>(Lazy Structure- Activity Relationships)</em> makes toxicity predictions for chemical structures. It
uses an automated and reproducible <em>read across</em> algorithm and shows rationales for predictions, applicability domain estimations and validation results in a clear
graphical interface.
Batch predictions are available <a href='mailto:helma@in-silico.ch'>on request</a>.
<h3><a href="https://nano-lazar.in-silico.ch">nano-lazar</a></h3>
<a href="https://nano-lazar.in-silico.ch"><code>nano-lazar</code></a> is a proof-of-concept application for read-across predictions of nanoparticle toxicities. The application was developed for the
<a href='http://www.enanomapper.net' rel='external'>eNanoMapper</a> project, and will not be maintained.
<h3><a href="https://aop.in-silico.ch">PubChem read across</a></h3>
<a href="https://aop.in-silico.ch">PubChem read across</a> predicts potential gene/protein targets of chemical structures. This is a quick prototype, that will not be maintained.
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<h2>Container</h2>
Our attempt to solve the problem of reproducible research. Our Docker repository provides self contained images, for easy installations and archival purposes.
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<h2><a href="https://git.in-silico.ch">Code</a></h2>
<a href="https://git.in-silico.ch">Source code</a> for our projects and publications.
<h2><a href="http://scholar.google.com/citations?sortby=pubdate&user=D7z0GgoAAAAJ">Publications</a></h2>
Please head to <a href="http://scholar.google.com/citations?sortby=pubdate&user=D7z0GgoAAAAJ">Google scholar</a>.
<h2>EU Projects</h2>
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<dt> <a href='http://www.enanomapper.net' rel='external'>eNanoMapper</a> </dt>
<dd> A Database and Ontology Framework for Nanomaterials Design and Safety Assessment </dd>
<dt> <a href='http://www.toxbank.net' rel='external'>ToxBank</a> </dt>
<dd> Supporting integrated data analysis and servicing of alternative testing methods in toxicology (WP leader) </dd>
<dt> <a href='http://www.birmingham.ac.uk/generic/modnanotox/index.aspx' rel='external'>ModNanoTox</a> </dt>
<dd> Modelling toxicity behaviour of engineered nanoparticles (WP leader) </dd>
<dt> <a href='http://www.opentox.org' rel='external'>OpenTox</a> </dt>
<dd> An open source predictive toxicology framework (scientific leader, WP leader) </dd>
<dt> <a href='http://www.sens-it-iv.org/' rel='external'>Sens-it-iv</a> </dt>
<dd> Novel testing strategies for in vitro assessment of allergens (WP leader) </dd>
<dt> <a href='http://www.scarlet-project.eu/' rel='external'>Scarlet</a> </dt>
<dd> Workshop on in silico methods for carcinogenicity and mutagenicity </dd>
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<h2>Awards</h2>
<ul>
<li>Research Price for Alternative Methods to Animal Experiments (German Federal Ministry on Consumer Protection, Food and Agriculture, 2005)
<li>Research Prize for Cancer Research without Animal Experiments (Doctors Against Animal Experiments, 2006)
</ul>
<h2>Contact</h2>
<em>in silico toxicology gmbh</em>
<br>Rastatterstrasse 41
<br>CH-4057 Basel, Switzerland
<p>Email:<a href='mailto:helma@in-silico.ch'>helma@in-silico.ch</a>
<br>Phone: +41-774339164
<hr>
© <a href='http://www.in-silico.ch/'>in silico toxicology gmbh</a> 2004-2020
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